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THE SCIENCE

Thync engineered a breakthrough neurostimulation technology for consumers. The fundamental mechanism of action centers on modulating cranial and spinal nerve pathways using a combination of targeted electrode placement and proprietary transdermal electrical neuromodulation waveforms. These nerve pathways synapse with key brainstem nuclei involved in modulating stress levels, mood, and sleep cycles.

Developing these algorithms involved years of research and testing over 1000 waveform iterations. The result of this research was a neurostimulation method that can lower stress and anxiety as well as elevate mood, and sleep quality.

Scientific Research and Usage

Thync was developed by a team of neuroscientists from MIT, Harvard, and Stanford. It has been extensively tested and used.
5
YEARS OF TESTING
5,000+
TESTING SESSIONS
1,300
NIGHTS OF MONITORED SLEEP
2,650,200+
MINUTES OF USE BY CUSTOMERS
Efficacy

Comprehensive scientific evidence for the efficacy of Thync’s neurostimulation algorithms against placebo was obtained using a multi-faceted approach. Biochemical, biometric and psychological assays were used to demonstrate the effectiveness in altering stress levels, mood, and sleep quality.

This research was conducted over the course of 150 internal studies with more than 5000 subject testing sessions. These studies have led to three publications.

In one internal study 109 subjects were blindly given real and placebo programs. Using a custom stress survey an overwhelming 88 subjects rated the real program as being more effective than placebo compared to only 9 people who rated the sham higher (P = 1.74 X 10-20).

Additional evidence includes:

  • Relaxation programs significantly lower tension and anxiety vs. placebo as assessed by the clinical Profile of Moods Scale.
  • Relaxation programs result in a 60% reduction in stress and a 30% reduction in anxiety vs. placebo using the clinical Depression Anxiety Stress Scale.
  • Relaxation programs significantly affect Heart Rate Variability vs. placebo.
  • Relaxation programs suppress a biometric measure of stress (galvanic skin conductance) by 53% compared to placebo treatment when subjects are subjected to a stress paradigm.
  • Relaxation programs significantly decrease a biochemical marker of stress levels (salivary amylase) compared to placebo.
  • Sleep programs lead to a significant improvement in sleep quality using clinical measures (Pittsburgh Sleep Quality Index and sleep actigraphy).
  • Sleep programs lead to a 37% reduction in middle of the night awakenings compared to placebo treatment.
Safety

The Thync system uses low electrical output levels that are approximately 1/5th of the current output of standard over-the-counter TENS and EMS/PMS devices. Nerve stimulation has been used for decades and has a low-risk safety profile. An independently conducted, extended use study of Thync’s neuromodulation strategy demonstrated that the incidence of side effects were equal to a sham protocol (no stimulation). In this study 100 participants receiving over 1,800 sessions showed no difference in headaches or other adverse events when compared to a sham treatment. In addition to this safety data, Edition One has over 2,500,000 minutes of use from customers supporting the conclusions from this safety data.